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KMID : 1137020080190010087
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Journal of Gynecologic Oncology
2008 Volume.19 No. 1 p.87 ~ p.92
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Endometrial stromal sarcoma associated with extrauterine endometriosis: a case report and Literature review
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Park Soo-Kyung
Lee Sun-Joo
Kwon Han-Sung
Sohn In-Sook
Lee Ji-Young
Kim Soo-Nyung
Cha Yun-Jeong
Lim So-Dug
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Abstract
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Endometrial stromal sarcoma (ESS) that arises from extrauterine endometriosis is a rare form of malignancy. We report
the case of a 37-year-old ESS patient with extrauterine endometriosis who was treated with ifosfamide/cisplatin
chemotherapy. A woman presented with epigastric pain and abdominal distension. Computed tomography imaging
revealed a profuse amount of ascites, including a 12.4×12.3 cm sized posterior cul-de-sac mass composed of solid and
cystic components. Cytoreductive surgery was performed to remove the mass and the histopathologic findings indicated
ESS associated with extrauterine endometriosis. Six cycles of combination chemotherapy [ifosfamide (5 g/m2) with
mesna (1 g/m2) and cisplatin (50 mg/m2) (IP)] were administered. After a six-month of disease-free interval, recurrent ESS developed in the pelvic cavity and in both lung fields. Megace medication decreased tumor marker CA-125 for six weeks. However, the patient expired sixteen months after the cytoreductive surgery. ESS associated with extrauterine
endometriosis showed response to IP chemotherapy and megace.
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KEYWORD
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Endometriosis, Extrauterine, Endometrial stromal sarcoma, Chemotherapy
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